Lee, H.N., Qiao, L., Zhong, Y., Mehta, S., Nishida, A.J., Rangamani, P., and Zhang, J. (2026). "Nanoscale Architecture Can Control Cellular Function." ACS Nano 20(34), 23756–23767.
Investigating how nanoscale architecture influences cellular function.
Khalilimeybodi, A., Qiao, L., Leung, A., McCulloch, A.D., Schenk, S., and Rangamani, P. (2026). "Systems modelling of mitochondrial dynamics in different exercise regimes." The Journal of Physiology 604, 6369–6390.
Systems-level mathematical modeling of mitochondrial dynamics under different exercise regimes.
Qiao, L., Alfonzo-Mendez, M., Taraska, J., and Rangamani, P. (2026). "Dynamics of the formation of flat clathrin lattices in response to growth factor stimulus." PLOS Computational Biology 22(3), e1014013. | Download Paper
Investigating the dynamics of flat clathrin lattice formation in response to growth factor stimulation.
Momtahan, N., McClain, A.K., Trementozzi, A., Sohn, S., Qiao, L., Zhao, C., Rangamani, P., Stachowiak, J.C., and Zoldan, J. (2026). "Connexin 43-Enriched Vesicles Improve Synchronization in hiPSC-Derived Cardiomyocytes." Advanced Science 13(33), e21032.
Investigating how Connexin 43-enriched vesicles improve synchronization in human induced pluripotent stem cell-derived cardiomyocytes.
Qiao, L., Khalilimeybodi, A., Linden-Santangeli, N., and Rangamani, P. (2024). "The evolution of systems biology and systems medicine: From mechanistic models to uncertainty quantification." Annual Review of Biomedical Engineering 27.
Reviewing the evolution of systems biology and systems medicine, from mechanistic modeling to uncertainty quantification.
Qiao, L., Getz, M., Gross, B., Tenner, B., Zhang, J., and Rangamani, P. (2024). "Spatiotemporal orchestration of calcium-cAMP oscillations on AKAP/AC nanodomains is governed by an incoherent feedforward loop." PLOS Computational Biology 20(10), e1012564.
Investigating the spatiotemporal regulation of calcium-cAMP oscillations through an incoherent feedforward loop.
Qiao, L., Sinha, S., Abd El-Hafeez, A.A., Lo, I.C., Midde, K.K., Ngo, T., Aznar, N., Lopez-Sanchez, I., Gupta, V., Farquhar, M.G., Rangamani, P., and Ghosh, P. (2023). "A eukaryotic circuit for secretion-coupled cellular autonomy." Molecular Systems Biology 19(4), e11127.
Investigating a eukaryotic regulatory circuit that couples secretion with cellular autonomy.
Qiao, L., Ghosh, P., and Rangamani, P. (2023). "Design principles of improving the dose-response alignment in coupled GTPase switches." npj Systems Biology and Applications 9(1), 3.
Identifying network design principles that improve dose-response alignment in coupled GTPase switches.
Qiao, L.*, Zhang, Z.*, Zhao, W.*, Wei, P., and Zhang, L. (2022). "Network design principle for robust oscillation behaviors with respect to the biological noise." eLife 11, e76188. (*These authors contributed equally.) | Download Paper
Identifying topological principles that enable robust oscillatory behaviors in noisy biological systems.
Guan, C.*, Qiao, L.*, Xiong, Y., Zhang, L., and Jiao, Y. (2022). "Coactivation of antagonistic genes stabilizes polarity patterning during shoot organogenesis." Science Advances 8(23), eabn0368. (*These authors contributed equally.)
Investigating how coactivation of antagonistic genes stabilizes polarity patterning during plant shoot organogenesis.
Zhao, W., Qiao, L., Yan, S., Nie, Q., and Zhang, L. (2021). "Mathematical modeling of histone modifications reveals the formation mechanism and function of bivalent chromatin." iScience 24(7), 102732. | Download Paper
A mathematical framework revealing how histone modifications shape bivalent chromatin formation and function.
Nie, Q., Qiao, L., Qiu, Y., Zhang, L., and Zhao, W. (2020). "Noise control and utility: from regulatory network to spatial patterning." Science China Mathematics 63, 425–440. | Download Paper
A review on noise control and its role in spatial patterning across biological systems.
Qiao, L.*, Zhao, W.*, Tang, C., Nie, Q., and Zhang, L. (2019). "Network topologies that can achieve dual function of adaptation and noise attenuation." Cell Systems 9(3), 271–285. (*These authors contributed equally.) | Download Paper
Theoretical exploration of network structures capable of both adaptation and noise attenuation.